Main J H, Mock D, Beagrie G S, Smith D C
J Biomed Mater Res. 1975 Jan;9(1):69-78. doi: 10.1002/jbm.820090107.
Powdered, sterilized zinc polycarboxylate was implanted subcutaneously in 56 young hamsters and 54 mice, using equal numbers of each sex, with 24 sham operated hamsters and 26 mice as controls. The hamsters were sacrificed after 15 months and the mice after 12. Implant material was recovered from one of 42 surviving mice and from 16 of 43 surviving hamsters. Benign adenomas of the gut, thyroid, sebaceous glands and ovary were found in 3 experimental mice and in one control. Benign adrenal adenomas were found in 3 experimental hamsters and in one control. One control hamster developed a rhabdomyosarcoma in a limb. One experimental hamster developed a leiomysarcoma in close relation to an implant.
将经消毒的聚羧酸锌粉末皮下植入56只幼年仓鼠和54只小鼠体内，每种性别数量相等，并设24只假手术仓鼠和26只假手术小鼠作为对照。15个月后处死仓鼠，12个月后处死小鼠。从42只存活小鼠中的1只以及43只存活仓鼠中的16只体内取出植入材料。在3只实验小鼠和1只对照小鼠中发现肠道、甲状腺、皮脂腺和卵巢的良性腺瘤。在3只实验仓鼠和1只对照仓鼠中发现良性肾上腺腺瘤。1只对照仓鼠肢体出现横纹肌肉瘤。1只实验仓鼠在植入物附近出现平滑肌肉瘤。
