King R N, Dunn H K, Bolstad K E
J Biomed Mater Res. 1975 Jul;9(4):157-65. doi: 10.1002/jbm.820090419.
Historically, the surgical repair of serious injuries to the flexor tendons of the hand have met with less than satisfactory clinical results. In an attempt to solve this problem, studies have been made on the design and testing of a Dacron polyester tendon prosthesis for complete replacement of the digital flexor tendon. The prosthesis attaches proximally at the anatomical musculotendon junction via collagen ingrowth into a fabric structure and in similar manner distally via bone ingrowth at the anatomical insertion site. These fabrics are continuous with the tendon body of the prosthesis consisting of an inextensible braided cord which is silicone rubber coated to prevent tissue adherence in the glide zone of the tendon bed. An added benefit of the prosthesis is a simple means of length adjustment which can easily be carried out on the operating table. Studies have been performed in both dogs and chickens which indicate that sufficient tissue ingrowth occurs at both the distal and proximal anastomoses for retention of full load bearing capability in these animals and that postoperative adhesions are negligible, if present at all. Full prostheses have been implanted in dogs for periods of over 1 year and chickens for 2 months. The chicken is the preferred animal model as a tendency for extensive scar tissue generation was shown in the dog. Both in vivo mechanical testing and histological characterization have been made on sacrificed animals which have received the full prostheses.
从历史上看，手部屈肌腱严重损伤的手术修复临床效果并不理想。为了解决这个问题，人们对一种用于完全替代指屈肌腱的涤纶聚酯肌腱假体进行了设计和测试研究。该假体近端通过胶原长入织物结构附着于解剖学肌肉 - 肌腱连接处，远端以类似方式通过骨长入解剖学插入部位。这些织物与假体的肌腱主体相连，假体的肌腱主体由不可伸展的编织绳组成，编织绳涂有硅橡胶以防止在肌腱床滑动区域发生组织粘连。该假体的另一个优点是长度调节方法简单，可在手术台上轻松进行。已经在狗和鸡身上进行了研究，结果表明在远端和近端吻合处都有足够的组织长入，使这些动物能够保留全部承重能力，并且术后粘连即使存在也可忽略不计。完整的假体已在狗体内植入超过1年，在鸡体内植入2个月。鸡是首选的动物模型，因为狗显示出有产生广泛瘢痕组织的倾向。对接受完整假体的处死动物进行了体内力学测试和组织学特征分析。
