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Identification of hepatic protein targets of the reactive metabolites of the non-hepatotoxic regioisomer of acetaminophen, 3'-hydroxyacetanilide, in the mouse in vivo using two-dimensional gel electrophoresis and mass spectrometry.

作者信息

Qiu Y, Benet L Z, Burlingame A L

机构信息

Department of Pharmaceutical Chemistry, University of California, San Francisco 94143-0446, USA.

出版信息

Adv Exp Med Biol. 2001;500:663-73. doi: 10.1007/978-1-4615-0667-6_99.

DOI:10.1007/978-1-4615-0667-6_99
PMID:11765013
Abstract
摘要

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Identification of hepatic protein targets of the reactive metabolites of the non-hepatotoxic regioisomer of acetaminophen, 3'-hydroxyacetanilide, in the mouse in vivo using two-dimensional gel electrophoresis and mass spectrometry.
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Subcellular binding and effects on calcium homeostasis produced by acetaminophen and a nonhepatotoxic regioisomer, 3'-hydroxyacetanilide, in mouse liver.对乙酰氨基酚和一种非肝毒性区域异构体3'-羟基乙酰苯胺在小鼠肝脏中产生的亚细胞结合及对钙稳态的影响
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