Hemminki K, Li X, Plna K, Granström C, Vaittinen P
Department of Biosciences, Karolinska Institute, Novum, Huddinge, Sweden.
Acta Oncol. 2001;40(6):772-7. doi: 10.1080/02841860152619214.
The Swedish Family-Cancer Database was expanded to include all Swedes born in 1932 and later (offspring) with their parents, totaling 10.2 million individuals. Cancer cases were retrieved from the Swedish Cancer Registry from the years 1958 to 1998, including over 1 million primary cancers and in situ tumors. Some 10%, of offspring diagnosed with cancer lack any parental information. Incidence rates of cancers were similar in the database and in the Cancer Registry to age 70, but at higher ages the rates in the Database were lower, probably because of selection. The familial risk for all types of cancer in offspring was 1.73 when a parent had the same type of cancer. The familial rates were increased for all main cancer sites, except for the upper aerodigestive tract, stomach, liver, pancreas and bone marrow (leukemia). The rates were 7.47 for thyroid, 4.69 for testis, and over 2.00 for melanoma, ovary, prostate, skin, endocrine glands and endometrium.
瑞典家庭癌症数据库进行了扩展，纳入了所有1932年及以后出生的瑞典人（后代）及其父母，总计1020万人。癌症病例从1958年至1998年的瑞典癌症登记处获取，包括超过100万例原发性癌症和原位肿瘤。约10%被诊断患有癌症的后代缺乏任何父母信息。在数据库和癌症登记处中，70岁之前癌症发病率相似，但在更高年龄时，数据库中的发病率较低，这可能是由于选择因素。当父母患有相同类型癌症时，后代患所有类型癌症的家族风险为1.73。除上呼吸道消化道、胃、肝、胰腺和骨髓（白血病）外，所有主要癌症部位的家族发病率均有所上升。甲状腺的发病率为7.47，睾丸为4.69，黑色素瘤、卵巢、前列腺、皮肤、内分泌腺和子宫内膜的发病率超过2.00。
