[爱泼斯坦-巴尔病毒（EBV）感染在腭扁桃体癌（PTC）致癌过程中的作用]

[The role of Epstein-Barr virus (EBV) infection in carcinogenesis of palatine tonsil carcinoma (PTC)].

作者信息

Kruk-Zagajewska A, Szkaradkiewicz A, Wierzbicka M, Jopek A, Woźniak A

机构信息

Katedra i Klinika Chorób Uszu, Nosa, Gardła i Krtani AM.

出版信息

Otolaryngol Pol. 2001;55(3):267-72.

PMID:11765441

Abstract

OBJECTIVES

Casual link of Epstein-Barr Virus (EBV) and endemically manifesting nasopharyngeal carcinoma has been already well documented. Our study, conducted in Karol Marcinkowski University of Medical Sciences in Poznań, aimed at examining whether EBV infection occurs also in patients with another tumor, palatine tonsil malignant neoplasms.

METHODS

The studies were performed on 20 patients, aged 32 to 80 years, in whom tonsil malignencies was diagnosed by histological methods. The treatment of choice was surgery. Sera of the patients was tested for EBV DNA (Sharp Signal System; Digene), IgM-anti-EBV antibodies (Behring), IgG-anti-EA antibodies (ETI-EA-G; Dia Sorin) and IgG-anti-VCA antibodies (ETI-VCA-G; Dia Sorin).

RESULTS

Serological exponents of reactivated EBV infection (serum IgG-anti-EA and IgG-anti-VCA antibodies) were observed in 12 patients. In parallel, ten of the patients demonstrated EBV DNA. In the remaining 8 patients, three manifested past EBV infection (positive IgG-anti-VCA) and five probed to be EBV negative.

CONCLUSIONS

The results indicated, that tonsil malignancies may be associated with EBV infection.

摘要

目的

爱泼斯坦-巴尔病毒（EBV）与地方性鼻咽癌的因果关系已有充分记录。我们在波兹南卡罗尔·马尔钦科夫斯基医科大学进行的研究旨在检查EBV感染是否也发生在患有另一种肿瘤——腭扁桃体恶性肿瘤的患者中。

方法

对20名年龄在32至80岁之间的患者进行了研究，这些患者通过组织学方法被诊断为扁桃体恶性肿瘤。首选治疗方法是手术。检测患者血清中的EBV DNA（Sharp Signal System；Digene）、IgM抗EBV抗体（贝林）、IgG抗EA抗体（ETI-EA-G；Dia Sorin）和IgG抗VCA抗体（ETI-VCA-G；Dia Sorin）。