蛇尾纲的成分。1. 从鳞蛇尾Ophiocoma scolopendrina中分离出三种神经节苷脂分子种类并确定其结构。

Constituents of ophiuroidea. 1. Isolation and structure of three ganglioside molecular species from the brittle star Ophiocoma scolopendrina.

作者信息

Inagaki M, Shibai M, Isobe R, Higuchi R

机构信息

Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.

出版信息

Chem Pharm Bull (Tokyo). 2001 Dec;49(12):1521-5. doi: 10.1248/cpb.49.1521.

DOI:10.1248/cpb.49.1521

PMID:11767069

Abstract

Three ganglioside molecular species, OSG-0 (1), OSG-1 (2), and OSG-2 (3) have been obtained from the polar lipid fraction of the chloroform/methanol extract of the brittle star Ophiocoma scolopendrina. The structures of these gangliosides have been determined on the basis of chemical and spectroscopic evidence as 1-O-[(N-glycolyl-alpha-D-neuraminosyl)-(2-->6)-beta-D-glucopyranosyl]-ceramide (1), 1-O-[8-O-sulfo-(N-acetyl-alpha-D-neuraminosyl)-(2-->6)-beta-D-glucopyranosyll-ceramide (2) and 1-O-[(N-glycolyl-alpha-D-neuraminosyl)-(2-->8)-(N-acetyl- and N-glycolyl-alpha-D-neuraminosyl)-(2-->6)-beta-D-glucopyranosyl]-ceramide (3). The ceramide moieties were composed of heterogeneous unsubstituted fatty acid, 2-hydroxy fatty acid and phytosphingosine units. Compounds 2 and 3 represent new ganglioside molecular species.

摘要

已从蛇尾纲动物 Ophiocoma scolopendrina 的氯仿/甲醇提取物的极性脂质部分中获得了三种神经节苷脂分子种类，即 OSG-0（1）、OSG-1（2）和 OSG-2（3）。这些神经节苷脂的结构已根据化学和光谱证据确定为 1-O-[(N-糖基-α-D-神经氨酰基)-(2→6)-β-D-吡喃葡萄糖基]-神经酰胺（1）、1-O-[8-O-磺基-(N-乙酰基-α-D-神经氨酰基)-(2→6)-β-D-吡喃葡萄糖基]-神经酰胺（2）和 1-O-[(N-糖基-α-D-神经氨酰基)-(2→8)-(N-乙酰基-和 N-糖基-α-D-神经氨酰基)-(2→6)-β-D-吡喃葡萄糖基]-神经酰胺（3）。神经酰胺部分由异质的未取代脂肪酸、2-羟基脂肪酸和植物鞘氨醇单元组成。化合物 2 和 3 代表新的神经节苷脂分子种类。