Kawatake Satoshi, Inagaki Masanori, Isobe Ryuichi, Miyamoto Tomofumi, Higuchi Ryuichi
Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Chem Pharm Bull (Tokyo). 2002 Oct;50(10):1386-9. doi: 10.1248/cpb.50.1386.
Two monomethylated GM(3)-Type ganglioside molecular species, 1 and 2, have been obtained from the polar lipid fraction of the chloroform/methanol extract of the starfish Luidia maculata. The structures of these gangliosides have been determined on the basis of chemical and spectroscopic evidence as 1-O-[8-O-methyl-(N-acetyl-alpha-D-neuraminosyl)-(2-->3)-beta-D-galactopyranosyl-(1-->4)-beta-D-glucopyranosyl]-ceramide (1) and 1-O-[8-O-methyl-(N-glycolyl-alpha-D-neuraminosyl)-(2-->3)-beta-D-galactopyranosyl-(1-->4)-beta-D-glucopyranosyl]-ceramide (2). The ceramide moieties were composed of heterogeneous unsubstituted fatty acid, 2-hydroxy fatty acid, sphingosine and phytosphingosine units. Compound 1, designated as LMG-3, represents new ganglioside molecular species. Compound 2 was a known ganglioside molecular species.
从海星黄斑海盘车的氯仿/甲醇提取物的极性脂质部分中获得了两种单甲基化的GM(3)型神经节苷脂分子种类，即1和2。基于化学和光谱证据，已确定这些神经节苷脂的结构分别为1-O-[8-O-甲基-(N-乙酰-α-D-神经氨酰基)-(2→3)-β-D-吡喃半乳糖基-(1→4)-β-D-吡喃葡萄糖基]-神经酰胺(1)和1-O-[8-O-甲基-(N-糖基-α-D-神经氨酰基)-(2→3)-β-D-吡喃半乳糖基-(1→4)-β-D-吡喃葡萄糖基]-神经酰胺(2)。神经酰胺部分由异质的未取代脂肪酸、2-羟基脂肪酸、鞘氨醇和植物鞘氨醇单元组成。化合物1被命名为LMG-3，代表一种新的神经节苷脂分子种类。化合物2是一种已知的神经节苷脂分子种类。
