Guan Y, He S, Dong J
PET Center, Huashan Hospital Affiliated to Fudan University, Shanghai 200235, China.
Zhonghua Yi Xue Za Zhi. 2001 Oct;81(19):1180-3.
To evaluate the accuracy and value of fluorine desoxy-glucose Positron emission tomography (FDG PET) imaging in the staging of non-small cell lung cancer (NSCLC).
A retrospective analysis of 82 patients with NSCLC confirmed by pathological examination was made to study the staging of whole-body FDG PET scanning compared with computerized tomography (CT).
The intake of FDG increased in the lung and metastatic foci among all 82 NSCLC patients. Whole-body PET scanning showed concentrated FDG in the 41 NSCLC patients with extrathoracic metastasis. The sensitivity and specificity of FDG PET in prediction of metastasis of mediastinal lymph nodes in patients with lung cancer were 94.4% and 100% respectively. The accuracy of PET scanning in staging of NSCLC was 95.2% in 42 patients who underwent operation after PET imaging. 37 NSCLC patients (45.1%) were restaged after the whole-body FDG PET scanning and their treatment programs were changed.
PET is more advantageous in pre-operational staging of NSCLC than other conventional imaging techniques, such as CT. For accurate positioning, PET should be combined with anatomical imaging techniques.
评估氟脱氧葡萄糖正电子发射断层扫描（FDG PET）成像在非小细胞肺癌（NSCLC）分期中的准确性和价值。
对82例经病理检查确诊的NSCLC患者进行回顾性分析，研究全身FDG PET扫描与计算机断层扫描（CT）相比的分期情况。
82例NSCLC患者的肺部及转移灶均出现FDG摄取增加。全身PET扫描显示41例有胸外转移的NSCLC患者FDG浓聚。FDG PET预测肺癌患者纵隔淋巴结转移的敏感性和特异性分别为94.4%和100%。在PET成像后接受手术的42例患者中，PET扫描对NSCLC分期的准确性为95.2%。37例NSCLC患者（45.1%）在全身FDG PET扫描后重新分期，其治疗方案发生改变。
PET在NSCLC术前分期方面比CT等其他传统成像技术更具优势。为实现准确定位，PET应与解剖成像技术相结合。
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