Richter D W, Heyde F, Gabriel M
J Neurophysiol. 1975 Sep;38(5):1162-71. doi: 10.1152/jn.1975.38.5.1162.
Respiratory neurons were recorded intracellularly within the lateral region of the lower brain stem of vagotomized and artificially ventilated cats. Bulbospinal, vagal, and antidromically nonresponsive types of neurons were distinguished by means of vagal and intraspinal stimulation. Almost all types of neurons discharged a burst of action potentials during one of the two phases of the central respiratory cycle, as indicated by phrenic nerve activity. The discharge pattern of the different types of neurons were described. The origin of the spntaneous changes of the membrane potential was investigated by measurements of the reversal potentials and membrane conductance changes. The results reveal that both inspiratory and expiratory types of neurons receive an excitatory input during their discharge period, and a reciprocal inhibitory input during their silent period. In addition, one type of neuron was described which receives inhibitory inputs during both inspiration and expiration. Recurrent inhibition, as indicated by hyperpolarizing postsynaptic potentials and membrane conductance changes following the antidromic action potential seems to exist only within the network of the vagal neurons. Suggestions are made about the functional organization of the neuronal network of the medullary respiratory system and the mechanism generating its rhythmic activity.
在切断迷走神经并进行人工通气的猫的脑桥下部外侧区域，对呼吸神经元进行细胞内记录。通过迷走神经和脊髓内刺激，区分出延髓脊髓型、迷走神经型和逆向无反应型神经元。如膈神经活动所示，几乎所有类型的神经元在中枢呼吸周期的两个阶段之一中都会发放一串动作电位。描述了不同类型神经元的放电模式。通过测量反转电位和膜电导变化，研究了膜电位自发变化的起源。结果显示，吸气型和呼气型神经元在放电期均接受兴奋性输入，在静息期接受相互抑制性输入。此外，还描述了一种在吸气和呼气期间均接受抑制性输入的神经元。如在逆向动作电位后出现的超极化突触后电位和膜电导变化所示，折返抑制似乎仅存在于迷走神经神经元网络中。对延髓呼吸系统神经元网络的功能组织及其节律性活动产生机制提出了相关建议。
