热休克蛋白100与杜氏利什曼原虫无鞭毛体阶段特异性A2蛋白
Heat shock protein 100 and the amastigote stage-specific A2 proteins of Leishmania donovani.
作者信息
Clos J, Klaholz L, Kroemer M, Krobitsch S, Lindquist S
机构信息
Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
出版信息
Med Microbiol Immunol. 2001 Nov;190(1-2):47-50. doi: 10.1007/s004300100078.
HSP100 protein in Leishmania spp. plays an important role for the survival and integrity of intracellular amastigotes. The A2 proteins of L. donovani are functionally linked to HSP100. There is evidence for an interdependence between these two proteins, which are both expressed predominantly in the amastigote stage of Leishmania donovani. Mutant strains lacking either of these proteins display very similar phenotypes, i.e. loss of virulence both in vivo and in vitro. Also, both proteins colocalise specifically to small foci within the cytoplasm of amastigotes.
利什曼原虫属中的热休克蛋白100（HSP100）蛋白对细胞内无鞭毛体的存活和完整性起着重要作用。杜氏利什曼原虫的A2蛋白在功能上与HSP100相关联。有证据表明这两种蛋白相互依存，它们都主要在杜氏利什曼原虫的无鞭毛体阶段表达。缺乏这两种蛋白中任何一种的突变株表现出非常相似的表型，即在体内和体外均丧失毒力。此外，这两种蛋白都特异性地共定位于无鞭毛体细胞质内的小病灶中。
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