钙和钠离子作为一种已知的蜗牛神经元动作电位中的电荷载体。
Calcium and sodium ions as charge carriers in the action potential of an identified snail neurone.
作者信息
Standen N B
出版信息
J Physiol. 1975 Jul;249(2):241-52. doi: 10.1113/jphysiol.1975.sp011013.
Abstract
- The soma of cell A in Helix aspersa produced action potentials in sodium-free or calcium-free saline, but not in saline with neither sodium nor calcium. 2. The axon had a sodium-dependent action potential. 3. Tetrodotoxin (5 x 10(-6) M) had no effect on the overshoot except at low external divalent ion concentrations. 4. The action potential in sodium-free saline was blocked by cobalt. 5. The slope of action potential overshoot against sodium concentration in the presence of 10 mM calcium was 10.5 mV/tenfold change. That of overshoot against calcium concentration in the presence of 75 mM sodium was 22 mV/tenfold change. 6. In sodium-free saline the slope of overshoot versus calcium concentration was 27 mV/tenfold change. 7. It is concluded that calcium is an important charge carrier in the action potential of cell A.
摘要
- 光滑双脐螺中细胞A的胞体在无钠或无钙盐溶液中能产生动作电位，但在既无钠也无钙的盐溶液中则不能。2. 轴突具有钠依赖性动作电位。3. 除了在低外部二价离子浓度下，河豚毒素（5×10⁻⁶ M）对动作电位的峰值没有影响。4. 无钠盐溶液中的动作电位被钴阻断。5. 在存在10 mM钙的情况下，动作电位峰值相对于钠浓度的斜率为10.5 mV/十倍变化。在存在75 mM钠的情况下，峰值相对于钙浓度的斜率为22 mV/十倍变化。6. 在无钠盐溶液中，峰值相对于钙浓度的斜率为27 mV/十倍变化。7. 得出的结论是，钙是细胞A动作电位中重要的电荷载体。
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