Topcu Ismail, Cüreoğlu Sebahattin, Yaramiş Ahmet, Tekin Muhammet, Oktay Faruk, Osma Ustün, Meric Faruk, Katar Selahattin
Department of Otorhinolaryngology, Faculty of Medicine, Dicle University, Kulak Burun Boğaz Anabilim Dai, 21280 Diyarbakir, Turkey.
Auris Nasus Larynx. 2002 Jan;29(1):11-4. doi: 10.1016/s0385-8146(01)00110-9.
To determine the characteristics of Brainstem auditory evoked response (BAER) findings in children with tuberculous meningitis (TBM) at admission.
Twenty-seven children with highly probable TBM were admitted to the University Hospital. The control group was 23 healthy, age and sex matched subjects. Brainstem response audiometry recording was performed in all patients and controls. Ninety dB sound pressure level (SPL) was used for comparisons. The main BAER measurements analysed were the I-III, III-V, I-V interpeak intervals. In statistical analysis, t-test for independent groups were performed. At the same time, for interpeak intervals, values exceeding 2.5 standard deviations (S.D.) above the means of the normal controls were considered abnormal. To the result of BAER findings, HL was classified as mild (until 40 dBHL), severe (until 80 dBHL) and total HL (no hearing was detected).
The latencies of interpeak intervals (except III-V latency at 10 per s) have significantly prolonged in comparison with controls. Mild HL was detected in four ears. In eight ears, any wave form could not be obtained at 110 dBSPL. Abnormal BAER result was seen in 13 of 54 ears (24%) at the click of 10 per s and five ears (12%) at the click of 50 per s.
Abnormal BAER result was seen in 24% of patients with TBM before treatment. Depending on these findings, it can be inferred that hearing impairments must be lower than those values which was detected by BAER during the acute phase of TBM, since the abnormal BAER may be reversible following the illness, returning to normal with recovery.
确定结核性脑膜炎（TBM）患儿入院时脑干听觉诱发电位（BAER）的表现特征。
27例高度疑似TBM的患儿入住大学医院。对照组为23名年龄和性别匹配的健康受试者。对所有患者和对照组进行脑干听觉诱发电位测听记录。采用90分贝声压级（SPL）进行比较。分析的主要BAER测量指标为I-III、III-V、I-V峰间期。统计学分析采用独立样本t检验。同时，对于峰间期，超过正常对照组均值2.5个标准差（S.D.）的值被视为异常。根据BAER检查结果，将听力损失（HL）分为轻度（直至40 dBHL）、重度（直至80 dBHL）和全聋（未检测到听力）。
与对照组相比，峰间期潜伏期（除10次/秒时的III-V潜伏期外）显著延长。4只耳检测到轻度HL。8只耳在110 dBSPL时未获得任何波形。在10次/秒的短声刺激下，54只耳中有13只（24%）BAER结果异常，在50次/秒的短声刺激下，有5只耳（12%）异常。
24%的TBM患儿在治疗前BAER结果异常。根据这些发现，可以推断在TBM急性期听力障碍程度肯定低于BAER检测到的值，因为异常的BAER在疾病后可能是可逆的，随着康复恢复正常。
