Mizokami Hiroyuki, Inokuchi Akira, Sawatsubashi Motohiro, Takagi Seiji, Tsuda Kuniyoshi, Tokunaga Osamu
Department of Otolaryngology-Head and Neck Surgery, Saga Medical School, Saga 849-8501, Japan.
Auris Nasus Larynx. 2002 Jan;29(1):77-82. doi: 10.1016/s0385-8146(01)00117-1.
Adenoid cystic carcinoma (ACC) of the lacrimal gland is the second most common epithelial tumor for which different biologic courses can be predicted by histologic criteria. Three main types of growth patterns, cribriform; tubular; and solid have been identified. Tumors with solid components frequently follow a more aggressive clinical course and show worse prognosis than those with other patterns. We herein report a case of ACC with wide and severe myoepithelial differentiation arising from the lacrimal gland and presenting with aggressive clinical behavior. Postoperative radiotherapy may be the treatment of choice to control residual lesions and provide long-term survival even in the case of incomplete resection. Despite extensive surgery and radiation therapy, the prognosis of these tumors, especially with solid components, remains extremely poor. Accurate diagnosis is important because tumor histopathology is generally believed to be the most significant factor in patient survival.
泪腺腺样囊性癌（ACC）是第二常见的上皮性肿瘤，其不同的生物学进程可通过组织学标准进行预测。已确定三种主要的生长模式，即筛状、管状和实性。具有实性成分的肿瘤通常临床进程更具侵袭性，预后比其他模式的肿瘤更差。我们在此报告一例起源于泪腺的具有广泛且严重肌上皮分化的ACC，其临床表现具有侵袭性。术后放疗可能是控制残留病灶并实现长期生存的首选治疗方法，即使在不完全切除的情况下也是如此。尽管进行了广泛的手术和放射治疗，但这些肿瘤，尤其是具有实性成分的肿瘤，预后仍然极差。准确的诊断很重要，因为一般认为肿瘤组织病理学是影响患者生存的最重要因素。
