Argyris Prokopios P, Pambuccian Stefan E, Cayci Zuzan, Singh Charanjeet, Tosios Konstantinos I, Koutlas Ioannis G
Department of Oral Pathology and Medicine, School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece.
Head Neck Pathol. 2013 Mar;7(1):85-92. doi: 10.1007/s12105-012-0383-2. Epub 2012 Jul 25.
Adenoid cystic carcinoma (AdCC) is the most frequent malignant neoplasm of the lacrimal glands. Like its salivary gland counterpart, lacrimal AdCC can rarely undergo high-grade transformation ("dedifferentiation"). We herein report the clinical, radiographic and microscopic findings of a lacrimal gland AdCC with high grade transformation, occurring in a 39-year-old female patient. In contrast to salivary gland AdCC with high-grade transformation, which usually shows a high grade component with "ductal" differentiation, in the case presented, the "dedifferentiated" component showed morphologic and immunohistochemical features of myoepithelial differentiation.
腺样囊性癌（AdCC）是泪腺最常见的恶性肿瘤。与其涎腺对应物一样，泪腺腺样囊性癌很少发生高级别转化（“去分化”）。我们在此报告一例发生于一名39岁女性患者的伴有高级别转化的泪腺腺样囊性癌的临床、影像学和显微镜检查结果。与通常显示具有“导管”分化的高级别成分的涎腺高级别转化腺样囊性癌不同，在本病例中，“去分化”成分显示出肌上皮分化的形态学和免疫组化特征。
