Gregg Edward W, Mangione Carol M, Cauley Jane A, Thompson Theodore J, Schwartz Ann V, Ensrud Kristine E, Nevitt Michael C
Division of Diabetes Translation, National Center for Chronic Disease and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA.
Diabetes Care. 2002 Jan;25(1):61-7. doi: 10.2337/diacare.25.1.61.
To examine the relationship between diabetes and the incidence of functional disability and to determine the predictors of functional disability among older women with diabetes.
We analyzed data from 8,344 women enrolled in the Study of Osteoporotic Fractures, a prospective cohort of women aged > or =65 years. Diabetes (n = 527, 6.3% prevalence) and comorbidities (coronary heart disease, stroke, arthritis, depression, and visual impairment) were assessed by questionnaire and physical examination. Incident disability, defined as onset of inability to do one or more major functional tasks (walking 0.25 mile, climbing 10 steps, performing household chores, shopping, and cooking meals), was assessed by questionnaire over 12 years.
The yearly incidence of any functional disability was 9.8% among women with diabetes and 4.8% among women without diabetes. The age-adjusted hazard rate ratio (HRR) of disability for specific tasks associated with diabetes ranged from 2.12 (1.82-2.48) for doing housework to 2.50 (2.05-3.04) for walking two to three blocks. After adjustment for potential confounders at baseline (BMI, physical activity, estrogen use, baseline functional status, visual impairment, and marital status) and comorbidities (heart disease, stroke, depression, and arthritis), diabetes remained associated with a 42% increased risk of any incident disability and a 53-98% increased risk of disability for specific tasks. Among women with diabetes, older age, higher BMI, coronary heart disease, arthritis, physical inactivity, and severe visual impairment at baseline were each independently associated with disability.
Diabetes is associated with an increased incidence of functional disability, which is likely to further erode health status and quality of life.
研究糖尿病与功能残疾发生率之间的关系，并确定老年糖尿病女性中功能残疾的预测因素。
我们分析了参加骨质疏松性骨折研究的8344名女性的数据，该研究是一项针对年龄≥65岁女性的前瞻性队列研究。通过问卷调查和体格检查评估糖尿病（n = 527，患病率6.3%）及合并症（冠心病、中风、关节炎、抑郁症和视力障碍）。通过问卷调查在12年期间评估新发残疾情况，新发残疾定义为开始无法完成一项或多项主要功能任务（步行0.25英里、爬10级台阶、做家务、购物和做饭）。
糖尿病女性中任何功能残疾的年发生率为9.8%，非糖尿病女性为4.8%。与糖尿病相关的特定任务的年龄调整后残疾风险率比（HRR）范围从做家务的2.12（1.82 - 2.48）到步行两到三个街区的2.50（2.05 - 3.04）。在对基线潜在混杂因素（BMI、身体活动、雌激素使用、基线功能状态、视力障碍和婚姻状况）及合并症（心脏病、中风、抑郁症和关节炎）进行调整后，糖尿病仍然与任何新发残疾风险增加42%以及特定任务残疾风险增加53 - 98%相关。在糖尿病女性中，年龄较大、BMI较高、冠心病、关节炎、身体不活动以及基线时严重视力障碍各自独立与残疾相关。
糖尿病与功能残疾发生率增加相关，这可能会进一步损害健康状况和生活质量。
