Smith S C, Smith E C, Taylor R L
Department of Animal and Nutritional Sciences, 13 Kendall Hall, University of New Hampshire, Durham, NH 03824-3590, USA.
J Hered. 2001 Sep-Oct;92(5):439-42. doi: 10.1093/jhered/92.5.439.
The inheritance pattern for susceptibility to spontaneous (noninduced) aortic atherosclerosis in pigeons was determined by crossbreeding and backcrossing experiments with atherosclerosis-susceptible White Carneau and atherosclerosis-resistant Show Racer breeds. Susceptibility, assessed by the presence of grossly visible lesions at the celiac bifurcation of the aorta at 3 years of age, demonstrated an inheritance pattern consistent with an autosomal recessive Mendelian trait. Cell culture studies indicated that susceptibility is a constitutive property of aortic cells as evidenced by vacuole formation and lipid content in smooth muscle cells from various tissues in susceptible pigeons.
通过对易患动脉粥样硬化的白卡诺鸽和抗动脉粥样硬化的赛鸽品种进行杂交和回交实验，确定了鸽子对自发性（非诱导性）主动脉粥样硬化易感性的遗传模式。通过在3岁时主动脉腹腔分叉处出现明显可见的病变来评估易感性，结果显示其遗传模式符合常染色体隐性孟德尔性状。细胞培养研究表明，易感性是主动脉细胞的一种固有特性，这在易患鸽子各种组织的平滑肌细胞中形成的液泡和脂质含量上得到了证明。
