The quantitative determination of griseofulvin by gas chromatography (ECD-GC).
作者信息
Suenaga Y, Yasukawa N
出版信息
Jpn J Antibiot. 1975 Oct;28(5):665-8.
PMID:1177355
Abstract
Serum and organ griseofulvin levels in guinea pigs and serum levels in patients who received a prolonged oral administration of griseofulvin were determined gas-chromatographically. In guinea pigs liver showed the highest concentration of griseofulvin, followed by kidney and serum in the decreasing order. The skin levels were 0.16 approximately 1.51 mug/g with a dose of 30 mg/kg. In humans it was proved that griseofulvin did not cause any accumulation in the serum with a dosage of 500 mg/day.
摘要
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