Skrabal F
Klin Wochenschr. 1975 Jul 1;53(13):629-32. doi: 10.1007/BF01469683.
In 16 normal subjects, in 29 patients with essential hypertension and in 25 patients with renal hypertension plasma renin activity was measured together with pulse rate and blood pressure under resting conditions and 15 minutes after the intravenous administration of 5 mg d-1-propranolol subsequently. Basal plasma renin activity (PRA) was correlated significantly to resting pulse rate in normal subjects and in patients with benign essential hypertension but not in patients with renal hypertension from chronic parenchymatous renal disease. In the normal subjects and in the patients with essential hypertension the decrease of not stimulated "basal" PRA 15 minutes after the administration of 5 mg d-1- propranolol was closely ralated to the initial plasma renin activity. In contrast, in the patients with well established renal hypertension the decrease of PRA was generally less pronounced or absent. Whereas in normal subjects as well as in patients with essentail hypertension in the sympathetic nervous system appears to be the major determinant for basal renin release, other factors, possibly the renal baroreceptors, may determine basal renin release in renal hypertension. This difference could possibley provide the basis for a simple biochemical test to differentiate between essential and renal hypertension.
在16名正常受试者、29名原发性高血压患者和25名肾性高血压患者中，在静息状态下以及随后静脉注射5毫克d-1-普萘洛尔15分钟后，测量了血浆肾素活性、脉搏率和血压。基础血浆肾素活性（PRA）在正常受试者和良性原发性高血压患者中与静息脉搏率显著相关，但在慢性实质性肾病所致肾性高血压患者中则无此相关性。在正常受试者和原发性高血压患者中，静脉注射5毫克d-1-普萘洛尔15分钟后，未受刺激的“基础”PRA的降低与初始血浆肾素活性密切相关。相比之下，在已确诊的肾性高血压患者中，PRA的降低通常不那么明显或没有降低。在正常受试者以及原发性高血压患者中，交感神经系统似乎是基础肾素释放的主要决定因素，而其他因素，可能是肾压力感受器，可能决定肾性高血压中的基础肾素释放。这种差异可能为区分原发性高血压和肾性高血压的简单生化检测提供依据。
