Sun Y, Qi D, Zhang B
Department of Stomatology, Beijing Tongren Hospital, Beijing 100730.
Zhonghua Kou Qiang Yi Xue Za Zhi. 1998 Jan;33(1):24-6.
To study the advantages of nitrous oxide sedation in teeth extraction.
112 patients were randomly allocated to four groups: 1) 60 mmol/L nitrous oxide, 2) 60 mmol/L nitrous oxide with estazolam, 3) 40 mmol/L nitrous oxide, 4) 40 mmol/L nitrous oxide with estazolam. The nitrous oxide was used for conscious sedation as an adjunct to local anaesthesia. 53 patients of control group underwent dental extraction with local anaesthesia only.
The postoperative MDAS scores of experimental group decreased and was significantly superior to control group (P < 0.01). The patients of experimental group showed a certain levels of sedation and partial amnesia. 97 of the 112 patients (86.62%) preferred inhalation sedation with nitrous oxide. There was no difference between the anxiolytic effects, sedative effects, amnestic effects of the four groups (P > 0.05). Estazolam as preoperative medieation did not show obvious coeffect with nitrous oxide.
Inhalation sedation with nitrous oxide can provide effects of goodquality antianxiery, sadation, amnesia in dental extraction.
研究氧化亚氮镇静在拔牙术中的优势。
112例患者被随机分为四组：1）60 mmol/L氧化亚氮；2）60 mmol/L氧化亚氮加艾司唑仑；3）40 mmol/L氧化亚氮；4）40 mmol/L氧化亚氮加艾司唑仑。氧化亚氮用于清醒镇静，作为局部麻醉的辅助手段。53例对照组患者仅采用局部麻醉进行拔牙。
实验组术后MDAS评分降低，且显著优于对照组（P < 0.01）。实验组患者表现出一定程度的镇静和部分遗忘。112例患者中有97例（86.62%）更喜欢氧化亚氮吸入镇静。四组的抗焦虑效果、镇静效果、遗忘效果之间无差异（P > 0.05）。艾司唑仑作为术前用药与氧化亚氮未显示出明显的协同作用。
氧化亚氮吸入镇静在拔牙术中可提供良好的抗焦虑、镇静、遗忘效果。
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