Wang C Y, Chiu C L, Har K O, Chan C, Rahman Z A A
Department of Anaesthesia, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
Int J Oral Maxillofac Surg. 2002 Oct;31(5):506-10. doi: 10.1054/ijom.2002.0293.
This study compares the use of inhalation sedation using sevoflurane (group S) with inhalation sedation using nitrous oxide (group N) in patients undergoing bilateral extraction of third molar teeth under local anaesthesia. The study was designed as a cross-over study. Seventeen ASA I, day surgery patients were studied. Patients were randomly allocated to receive either 8 l/min 50% nitrous oxide in oxygen (group N) or same flow of 1% sevoflurane (group S) for the first procedure. Each patient then had the alternate method of sedation for the second procedure. There were no significant differences between the methods in patient co-operation and surgeon's satisfaction with sedation. Psychomotor tests were comparable in both groups. The patients were significantly more sedated in the group S compared to group N (P=0.004). Significantly more patients complained of an unpleasant odour group S (P<0.01) but none withdrew from the study for this reason. No adverse cardiorespiratory effects resulted from sevoflurane or nitrous oxide sedation. Both methods gave good amnesia during the procedure. There was high acceptance of both methods and the patients rated the technique as equally satisfactory. We conclude that inhalation sedation with sevoflurane is a suitable alternative method to nitrous oxide sedation.
本研究比较了在局部麻醉下接受双侧第三磨牙拔除术的患者中，使用七氟醚进行吸入镇静（S组）与使用氧化亚氮进行吸入镇静（N组）的情况。该研究设计为交叉研究。对17例ASA I级日间手术患者进行了研究。患者被随机分配在第一次手术中接受8升/分钟的50%氧化亚氮/氧气混合气（N组）或相同流速的1%七氟醚（S组）。然后，每位患者在第二次手术中采用另一种镇静方法。两种方法在患者配合度和外科医生对镇静的满意度方面无显著差异。两组的心理运动测试结果相当。与N组相比，S组患者的镇静程度明显更高（P = 0.004）。S组中抱怨有难闻气味的患者明显更多（P < 0.01），但无人因此退出研究。七氟醚或氧化亚氮镇静均未产生不良心肺效应。两种方法在手术过程中均能产生良好的遗忘效果。两种方法的接受度都很高，患者对这两种技术的满意度相当。我们得出结论，七氟醚吸入镇静是氧化亚氮镇静的一种合适替代方法。
