Wang Q, Wu Z, Shi J
College of Stomatology, Fourth Military Medical University, Xi'an 710032.
Zhonghua Kou Qiang Yi Xue Za Zhi. 1998 Jan;33(1):27-9.
To evaluate the effects of BMP on the repair of animal periodontal defects by using GTR technique.
30 experimental mandibular buccal alveolar periodontal defects were produced surgically around premolar and molar teeth in 8 young mongrel dogs. The exposed root surfaces were curetted to remove the periodontal ligament and the cementum. The defects were devided into 3 equal groups (collagen, collagen + BMP, control). The results were examined histologically 1 month and 3 months respectively.
In experimental groups the JE downgrowth was inhibital in the early healing, and the new attachment formation was promoted while comparing with the controls. Compound membrane (with BMP) showed the capacity to support more new bone and cementum formation than the other two groups.
It is suggested that exogenous BMP can be used in GTR technique to promote periodontal regeneration.
通过应用引导组织再生(GTR)技术,评估骨形态发生蛋白(BMP)对动物牙周缺损修复的影响。
在8只年轻杂种犬的前磨牙和磨牙周围手术制造30个实验性下颌颊侧牙槽骨牙周缺损。刮除暴露的根面以去除牙周膜和牙骨质。将缺损分为3组(胶原、胶原+BMP、对照组),每组10个缺损。分别于术后1个月和3个月进行组织学检查。
与对照组相比,实验组在早期愈合中牙龈上皮附着生长受到抑制,新附着形成得到促进。复合膜(含BMP)比其他两组显示出支持更多新骨和牙骨质形成的能力。
提示外源性BMP可用于GTR技术以促进牙周组织再生。