Chen L, Yao Y, Yang M
Department of Obstrics and Gynecology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China.
Zhonghua Fu Chan Ke Za Zhi. 2000 Mar;35(3):142-4.
To investigate c-myc proto-oncogene expression of uterine spiral arteries in pregnancy induced hypertension (PIH) and the relationship of this expression with vascular smooth muscle cell (VSMC) proliferation in uterine spiral arteries of PIH.
Forty-nine placental bed biopsies, 29 from women with PIH and 20 from normotensive pregnant women, were taken during cesarean section. The expression of c-myc in uterine spiral arteries was detected and localized by in situ hybridization. Histological changes of placental bed biopsies were evaluated by HE staining.
The positive rate of c-myc was 63.6% (7/11) in moderate PIH and 72.2% (13/18) in severe PIH respectively. They were significantly higher than that in normotensive pregnancy (P < 0.05, P < 0.01, Fisher exact test). 54.5% (6/11) of moderate PIH and 55.6% (10/18) of severe PIH had VSMC proliferation. This was only 10.0% (2/20) in normotensive pregnancy. It was significantly lower than those of moderate and severe PIH (P < 0.05, P < 0.005, Fisher exact test). In PIH cases the VSMC proliferation in uterine spiral arteries was correlated with higher c-myc expression (chi-square test, P = 0.0093).
c-myc expression is higher in VSMC of uterine spiral arteries in PIH. VSMC Proloferates obviously in uterine spiral arteries of PIH cases. VSMC proliferation in PIH may be associated with c-myc expression.
研究妊娠高血压综合征（PIH）患者子宫螺旋动脉中c-myc原癌基因的表达及其与PIH患者子宫螺旋动脉血管平滑肌细胞（VSMC）增殖的关系。
剖宫产时取49例胎盘床组织活检标本，其中29例来自PIH患者，20例来自血压正常的孕妇。采用原位杂交法检测并定位子宫螺旋动脉中c-myc的表达。通过苏木精-伊红（HE）染色评估胎盘床活检组织的组织学变化。
中度PIH患者c-myc阳性率为63.6%（7/11），重度PIH患者为72.2%（13/18），均显著高于血压正常妊娠组（P<0.05，P<0.01，Fisher精确检验）。中度PIH患者中54.5%（6/11）、重度PIH患者中55.6%（10/18）出现VSMC增殖，而血压正常妊娠组仅为10.0%（2/20），显著低于中度和重度PIH组（P<0.05，P<0.005，Fisher精确检验）。在PIH病例中，子宫螺旋动脉VSMC增殖与较高的c-myc表达相关（卡方检验，P = 0.0093）。
PIH患者子宫螺旋动脉VSMC中c-myc表达较高。PIH患者子宫螺旋动脉中VSMC明显增殖。PIH患者VSMC增殖可能与c-myc表达有关。
