[促排卵治疗对多囊卵巢综合征相关性不孕患者子宫内膜整合素αvβ3表达的影响]

[Effects of ovulation induction therapies on endometrial integrin alpha v beta 3 expression in patients with polycystic ovarian syndrome related infertility].

作者信息

Wang Y, Chen Y, Li M

机构信息

Department of Obstetrics and Gynecology, Third Clinical Hospital, Beijing Medical University, Beijing 100083, China.

出版信息

Zhonghua Fu Chan Ke Za Zhi. 2000 Mar;35(3):163-5.

PMID:11775896

Abstract

OBJECTIVE

To study the endometrial integrins alpha v beta 3 expressions during mid-luteal(ML) phase in polycystic ovarian syndrome (PCOS) related infertile patients receiving ovulation induction therapies.

METHODS

Immunohistochemical methods using monoclonal antibody against integrins alpha v beta 3 were performed on endometrium of ML phase obtained from 22 normal subjects and 40 PCOS related anovulatory patients who underwent ovulation induction therapy by one of the following regimens: clomiphene citrate (CC) + human chorionicgonadotropin (hCG), CC + human menopausal gonadotropin (hMG) + hCG, or gonadotropin-releasing hormone agonist + hMG + hCG.

RESULTS

The expressions of endometrial integrin alpha v beta 3 during ML phase in GnRHa + hMG + hMG + hCG cycles were similar with those in normal natural cycles, but were weaker in CC + hCG, CC + hMG + hCG cycles as compared with controls.

CONCLUSION

CC + hCG, CC + hMG + hCG regimens may induce decline of endometrial receptivity in ML phase.

摘要

目的

研究接受促排卵治疗的多囊卵巢综合征（PCOS）相关不孕患者黄体中期（ML）子宫内膜整合素αvβ3的表达情况。

方法

采用抗整合素αvβ3单克隆抗体的免疫组织化学方法，对22名正常受试者以及40名接受促排卵治疗的PCOS相关无排卵患者的ML期子宫内膜进行检测。这些患者采用以下方案之一进行促排卵治疗：枸橼酸氯米芬（CC）+人绒毛膜促性腺激素（hCG）、CC+人绝经期促性腺激素（hMG）+hCG，或促性腺激素释放激素激动剂+hMG+hCG。