Li M, Li B, Niu Z
Department of Obstetrics and Gynecology, First Hospital of Shanxi Medical University, Taiyuan 030001, China.
Zhonghua Fu Chan Ke Za Zhi. 2000 Mar;35(3):175-7.
To study the effects of epidermal growth factor (EGF) on uterine leiomyoma and the relationship of EGF and estrogen, progesterone.
Fourty patients with uterine leiomyoma and twenty normal women were studied. Serum EGF level was determined by radioimumunoassay, estradiol (E2) and progesterone (P) levels were measured by enzyme marked monoclonal antibody assay.
Serum EGF, E2 and P levels in observed group were significantly higher than those in control group during secretive phase (P < 0.005). The serum EGF level in observed group during prolifrative phase was significantly higher than that of secretive phase (P < 0.05). The serum EGF level increased while uterus enlarged; EGF wasn't related to E2(r = 0.25, P > 0.05) and was related to P (r = 0.71, P < 0.005). The EGF level was the highest when E2 and P both increased.
EGF has the effect on growth of uterine leiomyoma. It is possible that EGF secretion can be stimulated by E2 and the effect of P is stronger than E2.
研究表皮生长因子（EGF）对子宫肌瘤的作用以及 EGF 与雌激素、孕激素的关系。
对 40 例子宫肌瘤患者和 20 例正常女性进行研究。采用放射免疫法测定血清 EGF 水平，用酶标单克隆抗体法检测雌二醇（E2）和孕激素（P）水平。
分泌期观察组血清 EGF、E2 和 P 水平显著高于对照组（P < 0.005）。增殖期观察组血清 EGF 水平显著高于分泌期（P < 0.05）。血清 EGF 水平随子宫增大而升高；EGF 与 E2 无关（r = 0.25，P > 0.05），与 P 有关（r = 0.71，P < 0.005）。当 E2 和 P 均升高时，EGF 水平最高。
EGF 对子宫肌瘤生长有作用。E2 可能刺激 EGF 分泌，且 P 的作用强于 E2。
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