米非司酮对早期妊娠妇女血清及绒毛中表皮生长因子浓度的影响
[Effect of mifepristone on the concentration of epidermal growth factor in serum and villi of early pregnant women].
作者信息
Yang Q, Yang X, Xu W
机构信息
First Affiliated Hospital of Hubei Medical University, Wuhan.
出版信息
Zhonghua Fu Chan Ke Za Zhi. 1998 May;33(5):271-3.
OBJECTIVE
To investigate the change of epidermal growth factor (EGF) concentration in serum and villi of early pregnant women and its possible effects by mifepristone.
METHODS
Twenty normal women as control and sixty-six early pregnant women were enrolled for study. Serum EGF, estradiol (E2) and progesterone (P) concentrations were measured with radioimmunoassay. EGF concentration in villi by surgical aspiration and mifepristone induced abortion were compared.
RESULTS
Serum EGF concentration in early pregnant women was significantly higher than that in non-pregnant women (P < 0.01). The serum EGF, E2 and P concentrations increased as pregnancy advanced (P < 0.05). The growth rate of gestational sac declined and serum EGF and P concentrations decreased slightly after administration of mifepristone. Villi EGF content in mifepristone group was significantly lower than that in surgical group (P < 0.05).
CONCLUSION
EGF may be involved in regulating embryo development. Mifepristone may interfere embryonic development via inhibiting EGF level.
目的
探讨早孕妇女血清及绒毛中表皮生长因子（EGF）浓度的变化及其可能受到米非司酮的影响。
方法
选取20名正常妇女作为对照，66名早孕妇女纳入研究。采用放射免疫法测定血清EGF、雌二醇（E2）和孕酮（P）浓度。比较手术吸宫及米非司酮药物流产绒毛中EGF浓度。
结果
早孕妇女血清EGF浓度显著高于未孕妇女（P < 0.01）。血清EGF、E2和P浓度随孕周增加而升高（P < 0.05）。服用米非司酮后，孕囊生长速度下降，血清EGF和P浓度略有降低。米非司酮组绒毛EGF含量显著低于手术组（P < 0.05）。
结论
EGF可能参与调节胚胎发育。米非司酮可能通过抑制EGF水平干扰胚胎发育。
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