Tanemura M, Nishikawa N, Kojima K, Suzuki Y, Suzumori K
Department of Obstetrics and Gynecology, Nagoya City University Medical School, Nagoya, Japan.
Ultrasound Obstet Gynecol. 2001 Oct;18(4):371-5. doi: 10.1046/j.0960-7692.2001.00536.x.
A 38-year-old multiparous woman was referred at 19 weeks' gestation because of hydrops fetalis. Ultrasonic examination revealed severe pleural effusion, ascites and skin edema. Detailed examination of the amniotic fluid, fetal blood and intrathoracic fluid led to a diagnosis of congenital fetal chylothorax. Repeated thoracocenteses were not effective in improving the hydrops fetalis. We introduced fetal treatment for the pleural effusion by an intrapleural injection of OK-432 at 23, 24 and 25 weeks' gestation. The pleural effusion was reduced by adhesion of the intrathoracic space and resulted in the delivery of a neonate who was healthy except for right renal dysfunction. Pulmonary hypoplasia was successfully prevented by OK-432.
一名38岁的经产妇在妊娠19周时因胎儿水肿前来就诊。超声检查发现严重的胸腔积液、腹水和皮肤水肿。对羊水、胎儿血液和胸腔内液体进行详细检查后诊断为先天性胎儿乳糜胸。反复胸腔穿刺对改善胎儿水肿无效。我们在妊娠23、24和25周时通过胸腔内注射OK-432对胎儿胸腔积液进行治疗。胸腔积液因胸腔粘连而减少，最终分娩出一名除右肾功能不全外健康的新生儿。OK-432成功预防了肺发育不全。
