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一种新型日本碳酸酐酶I变体CA 长崎1（第76位精氨酸突变为谷氨酰胺）的化学特征分析

Chemical characterization of a new Japanese variant of carbonic anhydrase I, CA INagasaki 1 (76 arg leads to gln).

作者信息

Goriki K, Tashian R E, Stroup S K, Yu Y S, Henriksson D M

出版信息

Biochem Genet. 1979 Jun;17(5-6):449-60. doi: 10.1007/BF00498883.

DOI:10.1007/BF00498883
PMID:117793
Abstract

A new inherited variant of carbonic anhydrase I (CA I), designated CA INagasaki 1 (CA INGS 1), was discovered during a survey of hemolysates from 5852 individuals from the cities of Hiroshima and Nagasaki in Japan. Analysis of the amino acid composition of a tryptic peptide from the CA INGS 1 variant indicated that a glutaminyl residue was substituted for an arginyl residue at position 76. Heat degradation studies showed that the CA INGS 1 variant was less stable than normal CA I. The CO2 hydrase and esterase activities of the normal and variant carbonic anhydrases I, as well as the relative amounts of the two enzymes in heterozygotes, were similar.

摘要

在对来自日本广岛和长崎两市的5852名个体的溶血产物进行调查期间，发现了一种新的碳酸酐酶I（CA I）遗传变体，命名为CA长崎1（CA INGS 1）。对来自CA INGS 1变体的胰蛋白酶肽段的氨基酸组成分析表明，第76位的精氨酰残基被谷氨酰胺酰残基取代。热降解研究表明，CA INGS 1变体比正常CA I稳定性更低。正常和变体碳酸酐酶I的二氧化碳水合酶和酯酶活性，以及杂合子中这两种酶的相对含量相似。

相似文献

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Chemical characterization of a new Japanese variant of carbonic anhydrase I, CA INagasaki 1 (76 arg leads to gln).一种新型日本碳酸酐酶I变体CA 长崎1（第76位精氨酸突变为谷氨酰胺）的化学特征分析
Biochem Genet. 1979 Jun;17(5-6):449-60. doi: 10.1007/BF00498883.
2
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Am J Hum Genet. 1972 May;24(3):330-8.

引用本文的文献

1
A polymorphic variant of human erythrocyte carbonic anhydrase I with a widespread distribution in Australian aborigines, CAI Australia-9 (8 Asp leads to Gly): purification, properties, amino acid substitution, and possible physiological significance of the variant enzyme.一种在澳大利亚原住民中广泛分布的人类红细胞碳酸酐酶I的多态变体，即CAI澳大利亚-9型（8号位天冬氨酸突变为甘氨酸）：该变体酶的纯化、特性、氨基酸替换及可能的生理意义
Biochem Genet. 1982 Oct;20(9-10):943-77. doi: 10.1007/BF00484071.
2
Amino acid substitution and chemical characterization of a Japanese variant of carbonic anhydrase I: CA I Hiroshima-1 (86 Asp replaced by Gly).碳酸酐酶I日本变异体的氨基酸取代与化学特性：CA I广岛-1（第86位天冬氨酸被甘氨酸取代）
Biochem Genet. 1981 Jun;19(5-6):535-49. doi: 10.1007/BF00484625.
3

本文引用的文献

1
Human carbonic anhydrases. VII. A new C type isozyme in erythrocytes of American Negroes.人类碳酸酐酶。VII。美国黑人红细胞中的一种新的C型同工酶。
Biochem Genet. 1971 Dec;5(6):497-504. doi: 10.1007/BF00485667.
2
Human carbonic anhydrases. IV. Properties of a mutant B type isozyme.人类碳酸酐酶。IV。一种突变B型同工酶的特性。
J Biol Chem. 1970 Oct 10;245(19):4913-9.
3
Characterization of a mutant human erythrocyte carbonic anhydrase: carbonic anhydrase Ic-Guam. The amino acid substitution and carboxylesterase and hydratase activities.
Human erythrocyte carbonic anhydrase polymorphism in Kenya.肯尼亚的人类红细胞碳酸酐酶多态性
Hum Genet. 1979 Nov;52(2):259-61. doi: 10.1007/BF00271581.
一种突变型人红细胞碳酸酐酶的特性：碳酸酐酶Ic-关岛型。氨基酸取代以及羧酸酯酶和水合酶活性。
Arch Biochem Biophys. 1966 Nov;117(2):320-7. doi: 10.1016/0003-9861(66)90419-x.
4
Purification and properties of human erythrocyte carbonic anhydrases.人红细胞碳酸酐酶的纯化及性质
J Biol Chem. 1966 Nov 10;241(21):5137-49.
5
Evidence for linkage of carbonic anhydrase isozyme genes in the pig-tailed macaque, Macaca nemestrina.猪尾猕猴（食蟹猴）碳酸酐酶同工酶基因连锁的证据。
Nat New Biol. 1973 Mar 14;242(115):55-6. doi: 10.1038/newbio242055a0.
6
Human carbonic anhydrases. XI. The complete primary structure of carbonic anhydrase B.人类碳酸酐酶。XI。碳酸酐酶B的完整一级结构。
J Biol Chem. 1973 Mar 25;248(6):1885-93.
7
Carbonic anhydrase isozymes in Cavia porcellus, Cavia aperea and their hybrids.豚鼠、草原豚鼠及其杂交种中的碳酸酐酶同工酶。
Comp Biochem Physiol B. 1972 Nov 15;43(3):743-7. doi: 10.1016/0305-0491(72)90159-9.
8
Amino acid sequence of human erythrocyte carbonic anhydrase B.人红细胞碳酸酐酶B的氨基酸序列。
Biochem Biophys Res Commun. 1972 Aug 7;48(3):670-7. doi: 10.1016/0006-291x(72)90400-7.
9
Human carbonic anhydrases. 8. Isolation and characterization of polymorphic form of a C type isozyme.人类碳酸酐酶。8. C型同工酶多态形式的分离与特性分析。
J Biol Chem. 1972 Jun 25;247(12):3761-6.
10
Crystal structure of human carbonic anhydrase C.人碳酸酐酶C的晶体结构。
Nat New Biol. 1972 Feb 2;235(57):131-7. doi: 10.1038/newbio235131a0.