多位点磷酸化与进入S期的倒计时
Multisite phosphorylation and the countdown to S phase.
作者信息
Deshaies R J, Ferrell J E
机构信息
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.
出版信息
Cell. 2001 Dec 28;107(7):819-22. doi: 10.1016/s0092-8674(01)00620-1.
Abstract
Remarkably, SCF(Cdc4) ubiquitin ligase binds and ubiquitinates Sic1 decorated with six, but not five, phosphates. This numerical wizardry suggests how analog inputs can be rectified to digital outputs. Unraveling the counting mechanism promises to generate new insights into the architecture of protein nanoprocessors.
摘要
值得注意的是，SCF（Cdc4）泛素连接酶能结合并泛素化带有六个而非五个磷酸基团的Sic1。这种数字魔法揭示了模拟输入如何转化为数字输出。解开计数机制有望为蛋白质纳米处理器的结构带来新的见解。
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