Liu X, He R, Chen W
Department of Oral and Maxillofacial Surgery, Suzhou Stomatological Hospital, Suzhou 215005, China.
Zhonghua Kou Qiang Yi Xue Za Zhi. 2000 Sep;35(5):343-5.
To elucidate the relationship between the expression of nuclear retinoic acid receptor beta (RAR beta) mRNA in oral carcinogenesis and squamous cell aberrant differentiation.
A total of 69 rat tongue carcinogenesis specimens induced by 4-nitroquinoline-1-oxide (4NQO) were detected for RAR beta mRNA by in situ hybridization.
With the progress of tongue carcinogenesis and epithelium cell disdifferentiation, the expression of RAR beta mRNA was down-regulated. The positive rate of RAR beta mRNA in normal, hyperplasia, mild-moderate dysplasia, severe dysplasia, in situ carcinoma and squamous cell carcinoma was 100.0%, 87.5%, 75.0%, 72.2%, 45.5% and 18.8%, respectively.
The down-regulation of RAR beta mRNA may be associated with the epithelium cell aberrant differentiation and may be an important molecular mechanism of oral carcinogenesis.
阐明核视黄酸受体β（RARβ）mRNA在口腔癌发生过程中的表达与鳞状细胞异常分化之间的关系。
采用原位杂交法检测69例4-硝基喹啉-1-氧化物（4NQO）诱导的大鼠舌癌发生标本中的RARβ mRNA。
随着舌癌发生及上皮细胞去分化进程，RARβ mRNA表达下调。RARβ mRNA在正常、增生、轻-中度发育异常、重度发育异常、原位癌及鳞状细胞癌中的阳性率分别为100.0%、87.5%、75.0%、72.2%、45.5%和18.8%。
RARβ mRNA表达下调可能与上皮细胞异常分化有关，可能是口腔癌发生的重要分子机制。
