Wang H, Wang C, Wang D
Department of Stomatology, General Hospital of PLA, Beijing 100853, China.
Zhonghua Kou Qiang Yi Xue Za Zhi. 2000 Mar;35(2):123-5.
To furnish an experimental basis of the early effects of rheumatoid arthritis (RA) on the temporomandibular joint (TMJ) by observing the histopathological changes of TMJ in the early stage of polyarthritis (PA) rats.
The animal model of PA was established by injecting Freund's complete adjuvant (FCA) into rats. The histopathological changes of the rats' ankle joint and TMJ were studied.
(1) The paw volume and the articular index of PA rats increased significantly, and symptoms of pronounced inflammation were present in the ankle joint specimens, which included proliferation of the synovium, infiltration with inflammatory cells, erosion into the articular cartilage and bone, and inflammatory exudation into the articular cavities. (2) The histopathology of TMJ of PA rats showed pronounced proliferation of the synovium cells, some lytic collagenous fibers and degenerative chondrocytes in the condyles, and exudated protein and desquamating cells in the articular cavities with some fibrinous adhesions.
Pronounced inflammation occurs in bilateral TMJ in early stage of PA rats. The examination, protection and treatment of TMJ for RA patients should be taken into account in the early stage.
通过观察多关节炎（PA）大鼠早期颞下颌关节（TMJ）的组织病理学变化，为类风湿关节炎（RA）对颞下颌关节的早期影响提供实验依据。
通过向大鼠注射弗氏完全佐剂（FCA）建立PA动物模型。研究大鼠踝关节和颞下颌关节的组织病理学变化。
（1）PA大鼠爪体积和关节指数显著增加，踝关节标本出现明显炎症症状，包括滑膜增生、炎性细胞浸润、关节软骨和骨侵蚀以及关节腔炎性渗出。（2）PA大鼠颞下颌关节组织病理学表现为滑膜细胞明显增生，髁突部分胶原纤维溶解和软骨细胞退变，关节腔有蛋白渗出和脱落细胞，伴有一些纤维性粘连。
PA大鼠早期双侧颞下颌关节出现明显炎症。类风湿关节炎患者颞下颌关节的检查、保护和治疗应在早期予以考虑。
