多奈哌齐治疗精神分裂症——有帮助吗？一项实验设计案例研究。
Donepezil in schizophrenia--is it helpful? An experimental design case study.
作者信息
MacEwan G W, Ehmann T S, Khanbhai I, Wrixon C
机构信息
Department of Psychiatry, St Vincent's Hospital, 749 W. 33rd Avenue, Vancouver, BC, Canada, V5Z 2K4.
出版信息
Acta Psychiatr Scand. 2001 Dec;104(6):469-72. doi: 10.1046/j.0001-690x.2001.acp1c008d.x.
OBJECTIVE
To assess the clinical and cognitive effects of adding donepezil, a reversible acetylcholinesterase inhibitor, to the risperidone treatment of a high functioning stable out-patient with schizophrenia.
METHOD
Case study using an experimental ABAB design. Assessments were completed objectively by standardized neuropsychological tests and clinical rating scales and subjectively with visual analogue scales.
RESULTS
Strong improvements attributable to donepezil were found for verbal fluency and the patient's subjective response. No adverse changes were noted in psychiatric symptoms or side effects.
CONCLUSION
Cholinergic enhancement as an adjunctive treatment in schizophrenia should be explored in larger controlled trials.
目的
评估在利培酮治疗高功能稳定门诊精神分裂症患者时添加多奈哌齐（一种可逆性乙酰胆碱酯酶抑制剂）的临床和认知效果。
方法
采用实验性ABAB设计的案例研究。通过标准化神经心理测试和临床评定量表进行客观评估，并使用视觉模拟量表进行主观评估。
结果
发现多奈哌齐可使言语流畅性和患者主观反应有显著改善。未观察到精神症状或副作用有不良变化。
结论
应在更大规模的对照试验中探索胆碱能增强作为精神分裂症辅助治疗的作用。
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