Straczkowski Marek, Lewczuk Piotr, Dzienis-Straczkowska Stella, Kowalska Irina, Stepień Agnieszka, Kinalska Ida
Departments of Endocrinology and Pediatric Neurology, Medical Academy, Bialystok, Poland; and the Max-Planck-Institute for Experimental Medicine, Goettingen, Germany.
Metabolism. 2002 Jan;51(1):75-8. doi: 10.1053/meta.2002.28095.
Intercellular adhesion molecule-1 (ICAM-1) is 1 of the possible factors linking obesity and diabetes with cardiovascular disease, however, the mechanism of the increase in ICAM-1 concentration in obesity remains unclear. Therefore, the aim of the present study was to assess plasma soluble ICAM-1 (sICAM-1) levels in obese subjects with normal glucose tolerance and to evaluate whether those levels may be related to insulin resistance and tumor necrosis factor-alpha (TNFalpha) system activity. The study was performed in 8 lean and 15 obese subjects. Anthropometric and biochemical parameters were measured, and insulin sensitivity was evaluated using the euglycemic hyperinsulinemic clamp technique (insulin infusion, 50 mU x kg(-1) x h(-1)). Obese subjects were markedly more hyperinsulinemic and insulin resistant and had higher plasma soluble TNF receptor 2 (sTNFR2) and sICAM-1 levels. sICAM-1 was related positively to body mass index (BMI), waist-to-hip ratio (WHR), percent of body fat, glycated hemoglobin (HbA(1c)), plasma insulin and triglycerides (TG), TNFalpha, and sTNFR2 and negatively to insulin sensitivity. Multiple regression analysis showed that only sTNFR2 and insulin sensitivity were independent predictors of sICAM-1 concentrations and were responsible for 66% of sICAM-1 variability. We conclude that an increase in plasma sICAM-1 concentration in obesity is related to TNFalpha system activation and insulin resistance.
细胞间黏附分子-1（ICAM-1）是将肥胖、糖尿病与心血管疾病联系起来的可能因素之一，然而，肥胖时ICAM-1浓度升高的机制仍不清楚。因此，本研究的目的是评估糖耐量正常的肥胖受试者血浆可溶性ICAM-1（sICAM-1）水平，并评估这些水平是否可能与胰岛素抵抗和肿瘤坏死因子-α（TNFα）系统活性有关。该研究对8名瘦人和15名肥胖受试者进行。测量了人体测量学和生化参数，并使用正常血糖高胰岛素钳夹技术（胰岛素输注，50 mU·kg⁻¹·h⁻¹）评估胰岛素敏感性。肥胖受试者明显更具高胰岛素血症和胰岛素抵抗，且血浆可溶性TNF受体2（sTNFR2）和sICAM-1水平更高。sICAM-1与体重指数（BMI）、腰臀比（WHR）、体脂百分比、糖化血红蛋白（HbA₁c）、血浆胰岛素和甘油三酯（TG）、TNFα以及sTNFR2呈正相关，与胰岛素敏感性呈负相关。多元回归分析表明，只有sTNFR2和胰岛素敏感性是sICAM-1浓度的独立预测因素，并且解释了sICAM-1变异性的66%。我们得出结论，肥胖时血浆sICAM-1浓度升高与TNFα系统激活和胰岛素抵抗有关。
