Neher E
An R Acad Nac Med (Madr). 2001;118(3):683-93.
Plastic changes in the connectivity between neurons underly the adaptive information processing of the central nervous system. The shortest forms of such plasticity are synaptic depression and facilitation, which happen on the subsecond time scale. New techniques allow to study synaptic transmission at unprecedented resolution and to dissect its various components, such as presynaptic Ca++ currents, Ca++ signals, and transmitter stores. Precise knowledge on the components, which are altered during plastic changes, is essential for understanding these important mechanisms.
神经元之间连接性的可塑性变化是中枢神经系统适应性信息处理的基础。这种可塑性的最短暂形式是突触抑制和易化，它们发生在亚秒级时间尺度上。新技术使人们能够以前所未有的分辨率研究突触传递，并剖析其各种成分，如突触前Ca++电流、Ca++信号和递质储存。准确了解在可塑性变化过程中发生改变的成分，对于理解这些重要机制至关重要。
