Wang C, Jin L, Chen J
Department of Obstetrics and Gynecology, Second Affiliated Hospital, Xiangya Medical College, Zhongnan University, Changsha 410011, China.
Zhonghua Fu Chan Ke Za Zhi. 2001 Apr;36(4):212-4.
To study the association of plasma von willebrand factor (vWF) and endothelin-1 (ET-1) levels in patients with pregnancy induced hypertension (PIH).
Plasma vWF and ET-1 were studied by ELISA method and immunoradiological method respectively in 36 patients with PIH, 18 normal pregnant women and 19 normal non-pregnant women.
Circulation levels of vWF and ET-1 were increased with increasing severity of the PIH. In mild PIH patients, the levels of plasma vWF [(135.9 +/- 30.9)%, (P > 0.05)] weren't significantly higher than those in healthy pregnant women [(131.6 +/- 39.2)%, (P > 0.05)], but the levels of ET-1 [(63.7 +/- 4.8) pg/L] were significantly higher than those in healthy pregnant women [(47.1 +/- 4.7) pg/L, (P < 0.01)]. There were significant differences between groups of moderate-severe PIH [vWF (174.4 +/- 35.4)%, ET-1 (92.6 +/- 19.1) pg/L]. There was a positive correlation between the plasma vWF level and ET-1 level.
The results suggested that plasma vWF and ET-1 concentration could be used as indicators for the severity of PIH.
研究妊娠高血压综合征（PIH）患者血浆血管性血友病因子（vWF）和内皮素-1（ET-1）水平的相关性。
分别采用酶联免疫吸附测定法（ELISA法）和免疫放射分析法对36例PIH患者、18例正常孕妇及19例正常非孕妇女进行血浆vWF和ET-1检测。
vWF和ET-1的循环水平随PIH病情加重而升高。轻度PIH患者血浆vWF水平[（135.9±30.9）%，（P>0.05）]与健康孕妇[（131.6±39.2）%，（P>0.05）]相比无显著升高，但ET-1水平[（63.7±4.8）pg/L]显著高于健康孕妇[（47.1±4.7）pg/L，（P<0.01）]。中重度PIH组[vWF（174.4±35.4）%，ET-1（92.6±19.1）pg/L]之间存在显著差异。血浆vWF水平与ET-1水平呈正相关。
结果提示血浆vWF和ET-1浓度可作为PIH病情严重程度的指标。
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