Chen Yihui, Graham Andrew, Potter William, Morgan Janet, Vaughan Lurine, Bellnier David A, Henderson Barbara W, Oseroff Allan, Dougherty Thomas J, Pandey Ravindra K
J Med Chem. 2002 Jan 17;45(2):255-8. doi: 10.1021/jm010400c.
The in situ conversion of the unstable bacteriochlorophyll a present in Rhodobacter sphaeroides produced highly stable bacteriopurpurin-18 which in a sequence of reactions was converted into a series of alkyl ether analogues of bacteriopurpurin-18-N-alkylimides with long wavelength absorption near 800 nm. The effective photosensitizers were found to localize in mitochondria but did not show any specific displacement of (3)H-PK11195, suggesting that the mitochondrial peripheral benzodiazepine receptor is not the cellular binding site for this class of compounds.
球形红细菌中存在的不稳定细菌叶绿素a原位转化生成了高度稳定的细菌紫红素-18，该物质在一系列反应中转化为一系列细菌紫红素-18-N-烷基酰亚胺的烷基醚类似物，其长波长吸收峰接近800 nm。研究发现，这些有效的光敏剂定位于线粒体，但未显示出对(3)H-PK11195的任何特异性取代，这表明线粒体外周苯二氮䓬受体不是这类化合物的细胞结合位点。
