Prandi D, Erlinger S, Roche-Sicot J, Husson J, Lortat-Jacob J L
Nouv Presse Med. 1975 Sep 20;4(30):2165-8.
The authors report the clinical, biochemical, histological and etiologic characteristics of 24 patients with the syndrome of benign intra-hepatic post-operative cholestasis. Jaundice appeared early in the post-operative period, from the first to the 12th post-operative day. All patients had received blood transfusions. In 23 patients, the post-operative course was complicated, chiefly by local infection or septicemia. Hyperbilirubinemia ranged from 2 to 28 mg per 100 ml and was mainly conjugated; serum alkaline phosphatase activity was normal or moderately elevated; in 3 patients, it was markedly elevated; serum glutamic-pyruvic transaminase activity was normal on 7 patients, moderatly increased in 15, and markedly increased in one. Liver histology was normal in 6 patients, and showed minimal lesions (cholestasis and slight portal inflammatory changes) in 3. Jaundice did not appear to modify the final outcome. It appears to be due both to increased production of bilirubin (as a result of blood transfusions) and to decreased excretion of bilirubin by the liver (as a result of the surgical operation and of infection).
作者报告了24例良性肝内术后胆汁淤积综合征患者的临床、生化、组织学及病因学特征。黄疸在术后早期出现，从术后第1天至第12天。所有患者均接受了输血。23例患者术后病程复杂，主要为局部感染或败血症。高胆红素血症范围为每100ml 2至28mg，主要为结合胆红素升高；血清碱性磷酸酶活性正常或中度升高，3例患者显著升高；7例患者血清谷丙转氨酶活性正常，15例中度升高，1例显著升高。6例患者肝脏组织学正常，3例显示轻微病变（胆汁淤积和轻微门静脉炎症改变）。黄疸似乎并未改变最终结局。其似乎是由于胆红素生成增加（输血所致）以及肝脏胆红素排泄减少（手术及感染所致）。
