McLemore L B, Horton J L, Antolak J A
Department of Radiation Physics, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Cardiovasc Radiat Med. 2001 Jul-Sep;2(3):181-90. doi: 10.1016/s1522-1865(01)00079-8.
This study was designed to assess the suitability of a 103Pd-implanted stent for use in intravascular brachytherapy.
A stent was modeled as a superposition of 201 identical struts and the EGS4/DOSRZ Monte Carlo code was used to calculate the dose distribution for each strut. To verify the simulation parameters, doses along the transverse axis of a Model 200 103Pd interstitial seed were calculated and compared to those calculated by the TG43 method.
Dose profiles within 1 mm of the stent's outer surface were heterogeneous and reflected the stent's structure. For a 2-mm outer-diameter 103Pd-implanted stent, approximately 2.68 x 10(7) Bq were required to deliver 31.5 Gy in 28 days at a distance of 0.5 mm along the perpendicular bisector from the stent's outer surface. The Monte Carlo simulation of the 103Pd seed showed relative doses within 7% of the values calculated by the TG43 method.
The dosimetry about a 103Pd-implanted stent suggests that the stent is suitable for use in intravascular brachytherapy.
本研究旨在评估103钯植入支架用于血管内近距离放射治疗的适用性。
将一个支架建模为201个相同支柱的叠加，并使用EGS4/DOSRZ蒙特卡罗代码计算每个支柱的剂量分布。为验证模拟参数，计算了200型103钯组织间籽源横轴上的剂量，并与通过TG43方法计算的剂量进行比较。
支架外表面1毫米内的剂量分布不均匀，反映了支架的结构。对于外径2毫米的103钯植入支架，沿支架外表面垂直平分线在0.5毫米处，要在28天内给予31.5戈瑞的剂量，大约需要2.68×10(7)贝可勒尔。103钯籽源的蒙特卡罗模拟显示相对剂量在TG43方法计算值的7%以内。
关于103钯植入支架的剂量学表明该支架适用于血管内近距离放射治疗。
