Couvreur G
Service de Neurologie, Hôpital Général, CHRU de Dijon, 21000 Dijon.
Rev Neurol (Paris). 2001 Sep;157(8-9 Pt 2):1143-51.
The aim of this paper is to review the quantitative methods used for assessing neurological status in multiple sclerosis patients. The Expanded Disability Status Scale (EDSS) is the most wide used. Its psychometric properties, validity, and inter- and intra-rater reliability are modest and responsiveness is weak. Similar results are obtained with the other scales used. The recently developed Multiple Sclerosis Functional Composite (MSFC) scale for clinical trials satisfies this requirement, but is not suitable for individual evaluation. There is no scale in French for assessment of cognitive disturbances and only one, the SEP-90, for quality of life. Brain and spinal cord abnormalities with conventional magnetic resonance imaging parameters (T1, T2-weighted and gadolinium enhanced images) have a weak relationship with disability. New magnetic resonance techniques (magnetic resonance spectroscopy and magnetized transfer imaging) would be more sensitive and should be further investigated.
本文旨在综述用于评估多发性硬化症患者神经状态的定量方法。扩展残疾状态量表（EDSS）是使用最广泛的。其心理测量特性、效度以及评分者间和评分者内信度一般，反应性较弱。使用的其他量表也得到了类似结果。最近为临床试验开发的多发性硬化症功能综合（MSFC）量表满足这一要求，但不适用于个体评估。法语中没有用于评估认知障碍的量表，用于评估生活质量的量表只有一个，即SEP - 90。传统磁共振成像参数（T1、T2加权和钆增强图像）显示的脑和脊髓异常与残疾的关系较弱。新的磁共振技术（磁共振波谱和磁化传递成像）可能更敏感，应进一步研究。
