[Diagnostic criteria of multiple sclerosis with reference to different clinical forms].

This paper reviews the validity of clinical diagnostic criteria and clinical course classification. Validation based on the pathological verification is not available. MS diagnosis remains clinical based on the objective demonstration of dissemination of lesions suggestive of MS in both time and space. Also clinical features are not specific and sensitive enough. MRI is primordial. MRI diagnosis criteria are discussed. Clinical course classification is difficult in regard to the extreme heterogeneity of the disease. Classical distinction between recurrent and progressive forms is reviewed from natural history studies and recent MRI and pathological findings. Recent studies focus on presentation including monosymptomatic disease and primary progressive forms.