Muehleman C, Berzins A, Koepp H, Eger W, Cole A A, Kuettner K E, Sumner D R
Department of Anatomy, Rush Medical College, Chicago, Illinois 60612, USA.
Anat Rec. 2002 Feb 1;266(2):81-6. doi: 10.1002/ar.10040.
Osteoarthritis (OA) is a common, disabling condition of synovial joints that can eventually lead to reduced, or lost, mobility. It is characterized by both articular cartilage degeneration and subchondral bone changes. However, a cause-and-effect relationship between the two tissues remains controversial. Increased subchondral bone density has been associated with early degenerative changes in the cartilage of knee, hip, and finger joints-joints in which progressive changes to OA are common. In contrast, the ankle joint is known to exhibit early cartilage changes, but is not prone to the development of OA. In the present study, it was found that cartilage degeneration on the talus is not associated with an increase in bone density, as assessed through peripheral quantitative computed tomography (pQCT).
骨关节炎（OA）是一种常见的、导致关节功能障碍的滑膜关节疾病，最终可能导致活动能力下降或丧失。它的特征是关节软骨退变和软骨下骨改变。然而，这两种组织之间的因果关系仍存在争议。软骨下骨密度增加与膝关节、髋关节和手指关节软骨的早期退行性改变有关，这些关节是OA常见的进展性改变部位。相比之下，已知踝关节会出现早期软骨改变，但不易发生OA。在本研究中，通过外周定量计算机断层扫描（pQCT）评估发现，距骨软骨退变与骨密度增加无关。
