Nozoe T, Saeki H, Ohga T, Sugimachi K
Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Ann Thorac Surg. 2001 Dec;72(6):1914-7. doi: 10.1016/s0003-4975(01)03091-0.
The aim of the current study was to find out the clinicopathologic characteristics of younger patients with squamous cell carcinoma of the esophagus.
A total of 259 patients with esophageal squamous cell carcinoma who had been treated by esophagectomy and reconstruction within 10 years between January 1990 and December 1999 were studied. Clinicopathologic characteristics were compared between 27 patients younger than 50 years and 232 patients 50 years and older.
A significant difference was observed with regard to the size of the tumor (6.3 +/- 3.8 cm in younger patients versus 5.0 +/- 2.4 cm in older patients; p = 0.017). The proportion of patients with TNM stage III or IV in younger patients (59.3%, 16 of 27) was significantly higher than that in older patients (38.3%, 89 of 232; p = 0.020). Nevertheless, no significant difference in the 1-, 3-, and 5-year survival rates was observed between younger patients (77.2%, 54.7%, and 54.7%, respectively) and older patients (81.9%, 54.2%, and 48.8%, respectively).
Although the prognosis of younger patients with esophageal squamous cell carcinoma did not differ from that of older patients, esophageal squamous cell carcinoma in younger patients has more malignant potential and aggressive activity.
本研究旨在探究年轻食管鳞状细胞癌患者的临床病理特征。
对1990年1月至1999年12月期间10年内接受食管切除术及重建术的259例食管鳞状细胞癌患者进行研究。比较了27例年龄小于50岁患者与232例年龄大于等于50岁患者的临床病理特征。
观察到肿瘤大小存在显著差异（年轻患者肿瘤大小为6.3±3.8 cm，老年患者为5.0±2.4 cm；p = 0.017）。年轻患者中TNM III期或IV期患者的比例（59.3%，27例中的16例）显著高于老年患者（38.3%，232例中的89例；p = 0.020）。然而，年轻患者（分别为77.2%、54.7%和54.7%）与老年患者（分别为81.9%、54.2%和48.8%）的1年、3年和5年生存率未观察到显著差异。
尽管年轻食管鳞状细胞癌患者的预后与老年患者无异，但年轻患者的食管鳞状细胞癌具有更高的恶性潜能和侵袭性。
