Criqui M H
Department of Family and Preventive Medicine, University of California, San Diego, La Jolla 92093, USA.
Vasc Med. 2001;6(3 Suppl):3-7. doi: 10.1177/1358836X0100600i102.
As many as 10 million people in the USA have peripheral arterial disease (PAD) with a prevalence over 10% in people aged more than 60 years old. Generally, men have a higher prevalence of PAD than women. The risk factors for PAD are similar to those for coronary artery disease (CAD) and cerebrovascular disease (CBVD), but diabetes and cigarette smoking have a particularly strong association with PAD. Patients with PAD also have CAD and CBVD as co-morbidities, although the extent of co-morbidity depends on the sensitivity of assessment. The risk of mortality is proportional to the severity of PAD, and the relative risk of all-cause mortality due to PAD is unaltered by the presence of CAD or CBVD. PAD is under-recognized and under-treated, even though it should be regarded as a severe disease leading to significant death and disability from stroke and myocardial infarction (MI). Thus, accurate diagnosis of PAD could provide an early indication of the need for intervention and help prevent future morbidity and mortality.
美国多达1000万人患有外周动脉疾病（PAD），在60岁以上人群中的患病率超过10%。一般来说，男性PAD的患病率高于女性。PAD的危险因素与冠状动脉疾病（CAD）和脑血管疾病（CBVD）相似，但糖尿病和吸烟与PAD的关联尤为密切。PAD患者也常合并CAD和CBVD，尽管合并症的程度取决于评估的敏感性。死亡风险与PAD的严重程度成正比，PAD导致的全因死亡相对风险不受CAD或CBVD存在的影响。尽管PAD应被视为一种导致中风和心肌梗死（MI）导致重大死亡和残疾的严重疾病，但它仍未得到充分认识和治疗。因此，准确诊断PAD可以为干预需求提供早期迹象，并有助于预防未来的发病和死亡。
