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肌肉表达:复杂组织中的基因分析

Muscular expressions: profiling genes in complex tissues.

作者信息

Hampson R, Hughes S M

机构信息

MRC Centre for Developmental Neurobiology and MRC Muscle and Cell Motility Unit, King's College London, Guy's Campus, London SE1 1UL, UK.

出版信息

Genome Biol. 2001;2(12):REVIEWS1033. doi: 10.1186/gb-2001-2-12-reviews1033. Epub 2001 Nov 22.

DOI:10.1186/gb-2001-2-12-reviews1033
PMID:11790260
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC138993/
Abstract

Gene-expression profiling has yielded important information about simple systems, but complex tissues have not yet been widely profiled. Four recent studies of mammalian skeletal muscles have added to the catalogs of their gene expression differences, but have yet to lead to better understanding of the molecular processes underlying their physiological differences.

摘要

基因表达谱分析已经产生了关于简单系统的重要信息,但复杂组织尚未得到广泛分析。最近四项关于哺乳动物骨骼肌的研究增加了其基因表达差异的目录,但尚未有助于更好地理解其生理差异背后的分子过程。

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本文引用的文献

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Calcineurin controls nerve activity-dependent specification of slow skeletal muscle fibers but not muscle growth.钙调神经磷酸酶控制慢肌纤维的神经活动依赖性特化,但不控制肌肉生长。
Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13108-13. doi: 10.1073/pnas.231148598. Epub 2001 Oct 23.
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The miracle of microarray data analysis.微阵列数据分析的奇迹。
Genome Biol. 2001;2(9):REPORTS4021. doi: 10.1186/gb-2001-2-9-reports4021. Epub 2001 Aug 29.
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Extraocular muscle is defined by a fundamentally distinct gene expression profile.眼外肌由一种根本不同的基因表达谱所定义。
Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12062-7. doi: 10.1073/pnas.211257298. Epub 2001 Sep 25.
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Regulation of CSF1 promoter by the SWI/SNF-like BAF complex.SWI/SNF样BAF复合物对CSF1启动子的调控
Cell. 2001 Aug 10;106(3):309-18. doi: 10.1016/s0092-8674(01)00446-9.
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Integrated genomic and proteomic analyses of a systematically perturbed metabolic network.对一个系统扰动的代谢网络进行综合基因组和蛋白质组分析。
Science. 2001 May 4;292(5518):929-34. doi: 10.1126/science.292.5518.929.
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Differential global gene expression in red and white skeletal muscle.红、白骨骼肌中的差异全局基因表达。
Am J Physiol Cell Physiol. 2001 Apr;280(4):C763-8. doi: 10.1152/ajpcell.2001.280.4.C763.
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Expression profiling in the muscular dystrophies: identification of novel aspects of molecular pathophysiology.肌营养不良症中的表达谱分析:分子病理生理学新方面的鉴定
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Genome Res. 1999 Dec;9(12):1313-20.