Wen Z, Xie L, Yan Z, Yao W, Chen K, Ka W, Chien S
Hemorheology Center, Department of Biophysics, School of Basic Medical Sciences, Peking University, Beijing, 100083, P.R. China.
Clin Hemorheol Microcirc. 2001;25(2):75-81.
A high-dose (7 Gy) whole-body 60Co irradiation for a short period caused disturbances of hematopoietic function. A decrease in the hematocrit of the circulating blood lasted for about 15 days, thus forming an anemic animal model. We studied the influence of high-dose 60Co irradiation on hemorheologic parameters: percentage of reticulocytes, RBC deformability, sedimentation rate and plasma fibrinogen concentration in the rabbit. It was found that the plasma fibrinogen concentration increased to twice more than control level and that percentage of reticulocytes in circulation disappeared immediately after irradiation. The deformation index of RBCs in shear flow decreased from a value of 58% down to a value of 42% in the first two weeks and gradually returned to control levels about 40 days after 60Co irradiation. Our results showed that a short period of high-dose 60Co irradiation caused severe and relatively long-lasting damage of hematopoietic system in animals' body.
短时间内给予大剂量（7戈瑞）全身60钴照射会导致造血功能紊乱。循环血液中血细胞比容下降持续约15天，从而形成贫血动物模型。我们研究了大剂量60钴照射对家兔血液流变学参数的影响：网织红细胞百分比、红细胞变形性、血沉率和血浆纤维蛋白原浓度。结果发现，血浆纤维蛋白原浓度增加至对照水平的两倍多，照射后循环中网织红细胞百分比立即消失。在前两周，剪切流中红细胞的变形指数从58%降至42%，60钴照射后约40天逐渐恢复到对照水平。我们的结果表明，短时间大剂量60钴照射会对动物体内造血系统造成严重且持续时间相对较长的损伤。
