Dietrichson O
Scand J Gastroenterol. 1975;10(6):617-24.
The diagnosis of chronic active (aggressive) hepatitis is based mainly on characteristic morphological changes. During a 7-year period, 85 cases were diagnosed in three medical departments in Copenhagen. This material is presented by clinical, biochemical, and serological variables at the time of diagnosis. None of the patients had simultaneously occurring Australia antigen and circulating autoantibodies. A comparison between two serologically homogeneous groups revealed significant differences in sex and age distribution onset of disease, and biochemical activity. The investigation suggests the existence of aetiologically different forms of chronic active hepatitis. Some cases are apparently caused by a persistent viral infection, while others may be due to a primary autoimmune mechanism. A considerable number of the patients stated that they had had prolonged intake of the potentially hepatotoxic laxative, oxyphenisatin. Nineteen patients were challenged with the drug and eight reacted with an increased biochemical activity in the liver disease. All these patients belonged to the group with circulating autoantibodies. It is possible that oxyphenisatin may be the primary cause of the chronic liver damage in some cases.
慢性活动性（侵袭性）肝炎的诊断主要基于特征性的形态学改变。在7年期间，哥本哈根的三个医学科室诊断出85例该疾病。本文根据诊断时的临床、生化和血清学变量呈现了这些病例资料。所有患者均未同时出现澳大利亚抗原和循环自身抗体。对两个血清学特征相同的组进行比较，结果显示在性别、年龄分布、发病情况及生化活性方面存在显著差异。该调查表明存在病因不同的慢性活动性肝炎形式。一些病例显然由持续的病毒感染引起，而其他病例可能归因于原发性自身免疫机制。相当多的患者表示他们长期服用了具有潜在肝毒性的泻药奥昔芬净。19名患者接受了该药激发试验，其中8名患者肝病的生化活性增强。所有这些患者都属于循环自身抗体阳性组。在某些病例中，奥昔芬净有可能是慢性肝损伤的主要病因。
