[Demonstration of dopaminergic receptors in human pituitary adenomas secreting prolactin].
作者信息
Bression D, Martres M P, Peillon F
出版信息
C R Seances Acad Sci D. 1979 Jul 9;289(2):133-5.
PMID:117916
Abstract
3H Domperidone binding on cellular membranes from human prolactin adenomas demonstrates the presence of two dopaminergic binding sites. The mean value of the dissociation constant (Kd) for five adenomas is of 0.29 +/- 0.14 nM for the first site and of 4.19 +/- 1.56 nM for the second site. The maximal number of binding sites (Bmax) varies from one adenoma to another. The binding is completely displaced at 30 nM of tritiated Domperidone by apomorohine, a specific dopaminergic agonist.
摘要
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