Bonnevie O
Scand J Gastroenterol. 1975;10(6):657-64.
The present prospective analysis shows that duodenal ulcers far more frequently than gastric ulcers are followed by a secondary ulcer. In patients with a gastric ulcer the cumulated 6-years probabilities of developing secondary ulcers thus was 8.8% while the corresponding risk of secondary ulcer in patients with duodenal ulcer was 3.7%. The probability of developing secondary ulcers was the same in men and women, and independent of the site and nature of the morphologic changes in the stomach and duodenum respectively. However, among patients with a gastric ulcer younger patients seem particularly apt to develop secondary ulcers. The total probability of having both types of ulcer diagnosed in patients fulfilling the criteria of the ulcer disease was estimated at approx. 12%; but certain observations indicate an even higher frequency of the disease.
目前的前瞻性分析表明，十二指肠溃疡之后发生继发性溃疡的频率远高于胃溃疡。因此，胃溃疡患者发生继发性溃疡的累积6年概率为8.8%，而十二指肠溃疡患者发生继发性溃疡的相应风险为3.7%。男性和女性发生继发性溃疡的概率相同，且分别独立于胃和十二指肠形态学改变的部位及性质。然而，在胃溃疡患者中，年轻患者似乎特别容易发生继发性溃疡。符合溃疡病标准的患者被诊断出患有两种类型溃疡的总概率估计约为12%；但某些观察结果表明该疾病的发生率甚至更高。
