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用于食管疾病的支架

Stents for Esophageal Disease.

作者信息

Moses Frank M., Wong Roy K.H.

机构信息

Gastroenterology Service, Department of Medicine, Walter Reed Army Medical Center,6900 Georgia Avenue, Washington DC 20307-5001, USA.

出版信息

Curr Treat Options Gastroenterol. 2002 Feb;5(1):63-71. doi: 10.1007/s11938-002-0008-z.

Abstract

Esophageal malignancies presenting with dysphagia from luminal obstruction generally are not resectable for cure, and palliative therapy is the primary focus. Self-expandable metal stents (SEMS) have replaced plastic stents as a primary mode of palliation for malignant esophageal obstruction because of the relative ease of insertion, lower initial morbidity, and larger stent diameter. Self-expandable metal stents are ideal for patients with midesophageal tumors. A majority of patients experience relief of dysphagia with SEMS and dietary modification, but the initial cost is high and early morbidity may be significant. The placement of SEMS across the gastroesophageal junction may result in free reflux that may improve with a stent containing a one-way gastric flap valve. The placement of SEMS in the cervical esophagus, although more difficult, less effective, and less well tolerated, also may be successful. Coated SEMS are a treatment of choice for individuals with tracheoesophageal fistula. Delayed complications occur in up to 40% of patients and include stent migration, bleeding, perforation, fistula formation, and occlusion. Most complications can be managed endoscopically and additional stents may be placed for tumor overgrowth. The comparison of three currently available SEMS for esophageal malignancy show no statistically significant differences with regard to ease of placement, effectiveness, complications, and mortality. The use of SEMS for patients with benign disease is still considered experimental.

摘要

因管腔阻塞而出现吞咽困难的食管恶性肿瘤通常无法通过手术治愈,姑息治疗是主要关注点。自膨式金属支架(SEMS)已取代塑料支架,成为恶性食管梗阻姑息治疗的主要方式,因为其插入相对容易、初始发病率较低且支架直径较大。自膨式金属支架对于食管中段肿瘤患者是理想的选择。大多数患者通过SEMS和饮食调整后吞咽困难得到缓解,但初始成本较高且早期发病率可能较高。将SEMS放置在胃食管交界处可能会导致自由反流,而带有单向胃瓣的支架可能会改善这种情况。将SEMS放置在颈段食管,虽然更困难、效果更差且耐受性更低,但也可能成功。带涂层的SEMS是治疗气管食管瘘患者的首选方法。高达40%的患者会出现延迟并发症,包括支架移位、出血、穿孔、瘘管形成和堵塞。大多数并发症可通过内镜处理,对于肿瘤过度生长可放置额外的支架。目前三种用于食管恶性肿瘤的SEMS在放置难易程度、有效性、并发症和死亡率方面没有统计学上的显著差异。将SEMS用于良性疾病患者仍被视为试验性的。

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