Falkson H C, Falkson G
S Afr Med J. 1975 Sep 6;49(38):1545-9.
Advanced Hodgkin's disease was considered incurable until 1966. The development of combined chemotherapy has led to intensIVe treatment and to cures. Results obtained in 104 patients treated according to acute leukaemia group B protocols are discussed. Staging according to the Rye classification was used, as these patients were treated from 1966 to 1971. Methodology and dosage schemes are discussed. Reponse rates reached 88%, with extended survival. The modifications of therapeutic schedules which led to long-term, unmaintained remissions, are explained. The 5-year survival rate of patients with Hodgkin's disease in stages III and iv who responded, was 82,7%. The effect of histological subclassification on the prognosis is considered. The importance of accurate documentation is stressed, and also the use of laparotomy to prove the staging of the disease so as not to deny the patient the benefit of potential cure with chemotherapy.
直到1966年，晚期霍奇金病还被认为是无法治愈的。联合化疗的发展带来了强化治疗并实现了治愈。本文讨论了按照急性白血病B组方案治疗的104例患者所取得的结果。由于这些患者是在1966年至1971年期间接受治疗的，因此采用了Rye分类法进行分期。文中讨论了方法和剂量方案。缓解率达到88%，生存期延长。解释了导致长期、无需维持的缓解的治疗方案修改情况。有反应的III期和IV期霍奇金病患者的5年生存率为82.7%。文中考虑了组织学亚分类对预后的影响。强调了准确记录的重要性，以及使用剖腹术来证实疾病分期的重要性，以免使患者无法从化疗潜在治愈中获益。
