Luo Y, Lin S, Irwin M E
Department of Statistics, Ohio State University, 1958 Neil Avenue, Columbus, OH 43210, USA.
Genet Epidemiol. 2001;21 Suppl 1:S24-9. doi: 10.1002/gepi.2001.21.s1.s24.
Bayesian Markov chain Monte Carlo (MCMC) segregation analysis for asthma was performed on the whole 1,544-member Hutterite pedigree. Heterogeneous and epistatic two-locus models and complex one-locus models were investigated, with trait loci postulated to be linked to markers in regions previously found to be possibly linked to asthma or atopy. The epistatic two-locus dominant-dominant model provided the best estimates, among the models investigated, in terms of prediction of population prevalence and relative risk for sibs of the affected.